Proline is a conditionally essential amino acid with a unique cyclic structure that confers special properties in protein architecture. Its biological roles include:
Maintaining connective tissue integrity as a critical component of collagen (skin, tendons, ligaments) and elastin
Ensuring protein structural stability by introducing conformational bends and stabilizing triple-helix collagen structures
Supporting wound healing through hydroxyproline synthesis for collagen cross-linking
Contributing to metabolic stability via its role in extracellular matrix remodeling and cellular stress response
Primary dietary sources: Bone broth, meat, poultry, fish, egg whites, dairy, soy, cabbage, mushrooms.
Inadequate proline may lead to impair collagen quality and tissue repair, and affect joint flexibility and skin elasticity
(Rare in balanced diets but may concern those with protein malnutrition)